Bilateral Renal agenesis

Bilateral Renal agenesis


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Bilateral Renal agenesis
Posted in 2013

 In bilateral renal agenesis neither kidney develops in the womb. (‘Bilateral’ means two sides.) Babies with this condition have no working kidneys.
Tests and diagnosis in pregnancy
The 20 week antenatal ultrasound scan looks at your baby growing in the womb. If the person doing the ultrasound cannot see kidneys, or can only see a small amount of tissue where the kidneys should be, bilateral renal will be suspected.
The scan also measures the amount of amniotic fluid (or liquor), the fluid that your baby floats in. The baby’s kidneys start making urine and pass this out into the amniotic fluid. This fluid protects your baby from getting hurt from the outside and helps his or her lungs mature so he or she is ready to breathe after birth. If there is very little or no fluid, this is another sign of a serious problem with the kidneys, such as bilateral renal agenesis .
Referral
If bilateral renal agenesis is suspected, you will be referred to specialist professionals as early as possible in the pregnancy. They may include:
foetal medicine specialist – a doctor who specialises in the health of unborn babies (foetuses)
obstetrician – a doctor who specialises in pregnancy, delivering babies and the care of women after childbirth
paediatrician – a doctor who treats babies, children and young people
paediatric nephrologist – a doctor who treats babies, children and young people with kidney problems
neonatologist – a doctor who specialises in newborn babies.
Further tests
You may need more ultrasound scans during the pregnancy to help find out whether it is bilateral renal agenesis
My advise
1....   Bilateral renal agenesis is the most profound form of renal agenesis (see this term), characterized by complete absence of kidney development, absent ureters and subsequent absence of fetal renal function resulting in Potter sequence with pulmonary hypoplasia related to oligohydramnios, which is fatal shortly after birth.
2....  Renal agenesis results from a development failure of the ureteric bud and the metanephric mesenchyme. In a few cases bilateral renal agenesis can be caused by mutations in the RET(10q11.2), FGF20 (8p22-p21.3) or the ITGA8 (10p13) genes. Maternal diabetes mellitus or use of specific drugs during pregnancy can also result in renal agenesis.
3...    Bilateral renal agenesis is characterized by absence of renal function and therefore urine production by the fetus, resulting in oligohydramnios. The disease is associated with restricted fetal movement and pulmonary hypoplasia. Newborns with bilateral renal agenesis can be expected to show features of the Potter sequence including wide-set eyes, flattened nose, receding chin and large, low-set ears deficient in cartilage.
4...    Transmission is autosomal recessive. In cases where a genetic cause is known, families may benefit from genetic counseling.
5....   Fetuses found to have bilateral renal agenesis are usually terminated, or if born, will die shortly after birth from lung hypoplasia.
6...    Fetal prevalence of bilateral renal agenesis in Europe has been estimated at 1/8,500.
7...    It is caused due to some unhealthy or unwanted medicines before or during pregnancy
8....   Follow healthy food before n during pregnancy

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