Exposing to Pesticides causes Infertility in Male
Exposing to Pesticides causes Infertility in Male
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Exposing to Pesticides causes Infertility in Male
Posted on 23rd January 2018
Pesticides and other poly chlorinated hydrocarbons: Exposure to pesticides affects many body organs including reproductive system. Spermatogenesis, testis weight and sperm parameters such as, sperm density and motility, sperm counts, viability, inducing sperm DNA damage, abnormal sperm morphology affected by organophosphoruses. It affects the male reproductive system by mechanisms to reduce the weight of testes, epididymis, seminal vesicle, and ventral prostate, seminiferous tubule degeneration and changes in hormone levels of testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) and also affects the antioxidant enzymes in testes, and inhibited testicular steroidogenesis are other possible mechanisms
Men working in the agriculture sector are at more than tenfold increased risk of infertility in comparison to those in other occupations . Exposure of the father to pesticides during the preconception period or prior can also increase the risk of having anencephalic child. Men engaged in agricultural practices adopting use of pesticides are at increased risk of fetal death from congenital anomalies, particularly where pesticides are used massively. Paternal pesticide exposure has been otherwise reported to decrease fertilizing ability of sperm in those seeking IVF treatment . Pre-conceptional paternal pesticide exposure is reportedly associated with an increased risk of acute lymphoblastic leukemia in children aged 0.9 years . 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic man-made chemicals. A study conducted by Mocarelli et al. (2000) reveals that a population exposed to TCDD was linked with lowered male to female sex ratio in offspring whose parental exposure was through paternal route rather than maternal.
My advise
1... Oxidative stress (OS) plays an important role in human reproduction. It arises as a consequence of excessive ROS production and/or impaired antioxidant defense mechanisms
2..... Owing to their deleterious effects on human spermatozoa, excessive ROS must be continuously inactivated to keep only a small amount necessary to maintain normal cell function
3.... Oxidative stress-mediated damage to the sperm plasma membrane may account for defective sperm function observed in a high proportion of infertile patients
4.... The most common ROS that have potential significance in reproductive biology, include the superoxide anion (O2-), hydrogen peroxide (H2O2), the peroxyl (ROO-) and the hydroxyl (OH-) radicals . Reactive oxygen species (ROS) has both physiological and pathological roles in male infertility. The physiological level of ROS plays a crucial role in processes such as maturation, capacitation, acrosomal reactions, and fertilization . On the other hand, pathological levels of ROS, which can originate from endogenous sources such as leukocytes and immature/abnormal spermatozoa
5.... Oxidative stress is not routinely checked in andrology lab, because of its cost and complexity of testing and the lack of a single standardized measure of oxidative stress. The assessment of quality of sperm DNA has become essential with the increase in the use of assisted reproductive techniques (ART) in infertility managment. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) techniques bypass several natural selection barriers that are present throughout the male and female reproductive tracts until the sperm enters the oocyte
6.... Investigations have shown disorder results into failure of ICSI and intrauterine insemination (IUI) and one of the main causes of defective off springs . The rate of live birth is low especially when sperm with DNA damage is used in ART. The H2O2 caused a dose-dependent deleterious effect on sperm DNA integrity and sperm function in both fertile and infertile group, however, in infertile group effect was more severe. Our previous study shows that DNA integrity of spermatozoa harshly deteriorate at 300 μM of H2O2 within 10 min of incubation period when incubated in vitro though, sperm motility, vitality and other sperm functions did not affected at this level.
7... I advise every person who supposed to expose pesticides should keep some plant in his residence to get oxygen which will nullify pesticides effect on him.
8... Drink sufficient water and eat fruits regularly
9... Lifestyle factors are amendable habits and ways of life that can greatly influence overall health and well being, including fertility. Advancing paternal age, occupation has been implicated in a broad range of abnormal reproductive and genetic outcomes. Lifestyle factors, including age when starting a family, nutrition, weight management, exercise, psychological stress, cigarette smoking, recreational and prescription drugs use, alcohol and caffeine consumption, may impact fertility
Brought to U...... htp://succcessgain.info
Brought to U....http://successgain.us and http://successgain.info
My memories
Exposing to Pesticides causes Infertility in Male
Posted on 23rd January 2018
Pesticides and other poly chlorinated hydrocarbons: Exposure to pesticides affects many body organs including reproductive system. Spermatogenesis, testis weight and sperm parameters such as, sperm density and motility, sperm counts, viability, inducing sperm DNA damage, abnormal sperm morphology affected by organophosphoruses. It affects the male reproductive system by mechanisms to reduce the weight of testes, epididymis, seminal vesicle, and ventral prostate, seminiferous tubule degeneration and changes in hormone levels of testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) and also affects the antioxidant enzymes in testes, and inhibited testicular steroidogenesis are other possible mechanisms
Men working in the agriculture sector are at more than tenfold increased risk of infertility in comparison to those in other occupations . Exposure of the father to pesticides during the preconception period or prior can also increase the risk of having anencephalic child. Men engaged in agricultural practices adopting use of pesticides are at increased risk of fetal death from congenital anomalies, particularly where pesticides are used massively. Paternal pesticide exposure has been otherwise reported to decrease fertilizing ability of sperm in those seeking IVF treatment . Pre-conceptional paternal pesticide exposure is reportedly associated with an increased risk of acute lymphoblastic leukemia in children aged 0.9 years . 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic man-made chemicals. A study conducted by Mocarelli et al. (2000) reveals that a population exposed to TCDD was linked with lowered male to female sex ratio in offspring whose parental exposure was through paternal route rather than maternal.
My advise
1... Oxidative stress (OS) plays an important role in human reproduction. It arises as a consequence of excessive ROS production and/or impaired antioxidant defense mechanisms
2..... Owing to their deleterious effects on human spermatozoa, excessive ROS must be continuously inactivated to keep only a small amount necessary to maintain normal cell function
3.... Oxidative stress-mediated damage to the sperm plasma membrane may account for defective sperm function observed in a high proportion of infertile patients
4.... The most common ROS that have potential significance in reproductive biology, include the superoxide anion (O2-), hydrogen peroxide (H2O2), the peroxyl (ROO-) and the hydroxyl (OH-) radicals . Reactive oxygen species (ROS) has both physiological and pathological roles in male infertility. The physiological level of ROS plays a crucial role in processes such as maturation, capacitation, acrosomal reactions, and fertilization . On the other hand, pathological levels of ROS, which can originate from endogenous sources such as leukocytes and immature/abnormal spermatozoa
5.... Oxidative stress is not routinely checked in andrology lab, because of its cost and complexity of testing and the lack of a single standardized measure of oxidative stress. The assessment of quality of sperm DNA has become essential with the increase in the use of assisted reproductive techniques (ART) in infertility managment. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) techniques bypass several natural selection barriers that are present throughout the male and female reproductive tracts until the sperm enters the oocyte
6.... Investigations have shown disorder results into failure of ICSI and intrauterine insemination (IUI) and one of the main causes of defective off springs . The rate of live birth is low especially when sperm with DNA damage is used in ART. The H2O2 caused a dose-dependent deleterious effect on sperm DNA integrity and sperm function in both fertile and infertile group, however, in infertile group effect was more severe. Our previous study shows that DNA integrity of spermatozoa harshly deteriorate at 300 μM of H2O2 within 10 min of incubation period when incubated in vitro though, sperm motility, vitality and other sperm functions did not affected at this level.
7... I advise every person who supposed to expose pesticides should keep some plant in his residence to get oxygen which will nullify pesticides effect on him.
8... Drink sufficient water and eat fruits regularly
9... Lifestyle factors are amendable habits and ways of life that can greatly influence overall health and well being, including fertility. Advancing paternal age, occupation has been implicated in a broad range of abnormal reproductive and genetic outcomes. Lifestyle factors, including age when starting a family, nutrition, weight management, exercise, psychological stress, cigarette smoking, recreational and prescription drugs use, alcohol and caffeine consumption, may impact fertility
Brought to U...... htp://succcessgain.info
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