Chemical contaminants causes male infertility
Chemical contaminants causes male infertility
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Chemical contaminants causes male infertility
Posted on 30th January 2018
The genetic basis of infertility has received increasing recognition in recent years. Several kinds of chromosomal abnormalities are associated with infertility: deletion, inversion, mutation, aneuploidy, and translocation. Of these, translocation is most common chromosomal abnormality. A study showed that the frequency of chromosomal translocations was 2.1% in infertile men. Chromosomal translocations can be of many types- Robertsonian translocation, reciprocal translocation and these account for 10% of the causes of male infertility . Robertsonian translocations are defined as translocations involving acrocentric chromosomes 13-15.21.22. Carriers of Robertsonian translocations are phenotypically normal; however, they exhibit reproductive dysfunction, such as oligospermia in males . It is now obvious that genetic etiology for infertility is an important cause of disrupted spermatogenesis. Genetic damage in sperm can occur at several levels, all of which have the potential to cause infertility in men. Sperm DNA is known to contribute one half of the genomic material to offspring. Thus, normal sperm genetic material is required for fertilization, embryo and fetal development and post-natal child well being . Various in vivo and in vitro studies have suggested that disturbances in the genomic organization in sperm nuclei are negatively correlated with the fertility potential of spermatozoa . Investigations have also shown that these disorders play an important role in failure of intracytoplasmic sperm injection (ICSI) and intrauterine insemination (IUI). In males the prevalence of genetic factors seems to be inversely related to the sperm count. Our earlier study was also documents a negative correlation between DNA damaged cells and sperm motility. There is a concern that these genetic abnormalities can be transmitted to the male progeny, who may subsequently have a more severe phenotype of infertility. The incidence of chromosome factors in infertile males ranges between 2 and 8% increased to 15% in azoospermic males in recent years . FSH is an important hormone which is required for initiation of spermatogenesis is requisite to monitor in infertile men from the point of therapeutics and clinical intervention. Normal FSH is indicative of germinal epithelial destruction, but elevated FSH is associated with both normal as well as aberrant spermatogenesis, where testicular histology could show Sertoli cell only (SCO) syndrome, Hypospermatogenesis is seen where the quantity of spermatogenesis is decreased and is known to be associated with either normal or elevated FSH. The rate of carry home alive and healthy birth is low especially when DNA damaged sperm is used in ART. Recurrent ART failure cause financial, emotional and psychological stress on the couples.
My advise
1.... Advancement in molecular biology enabled the identification and characterization of underlying genetic causes of male infertility. Genetic causes must be sought by systematic evaluation of infertile men and affected couples informed about the implications of such diagnoses for assisted reproductive technology outcome and their potential offspring. An association between human male infertility and chromosomal anomalies has been known for a long time. The incidence of karyotype abnormalities among patients with infertility has been reported to range between 2% to 21%, being low among azoospermic men
2.... .The possible association between chromosomal abnormalities and male infertility became evident following the result of the first large karyo type survey involving sub fertile males . The Y chromosome in mammals carries the gene that switches the development of the indifferent gonad from the default female pathway to the male pathway and results in the development of the testis . Long ago macroscopic deletions in the long arm of Y chromosome were suggested to be responsible for azoospermia . With the advancement in molecular biology, three non-overlapping regions, to as azoospermia factor (AZF a, b and c from proximal to distal Yq) have been defined as spermatogenesis loci
3....... The AZF microdeletions are the prevalent cause of male factor infertility. Germ cell development is under the control of a large number of genes on auto somes and on the Y chromosome. The long arm of the Y chromosome contains genes and gene families involved in spermatogenesis and are critical for germ cell development and differentiation. In 1992, Vollrath and colleagues constructed a 43 interval deletion map of a human Y chromosome that contained on ordered array of sequence tagged sites (STS) that spanned the entire length of the Y chromosome.
4..... The genes critical for spermatogenesis are located on the long arm of the Y chromosome in deletion interval 5 and 6 bend 11.23. This region is referred to as the AZF as the most severe phenotype associated with its deletion is azoospermia. The AZFa locus is located on proximal Yq11 (Yq 11.21), while AZFb and AZFc are located on distal Yq 11 (Yq 11.23). Deletion of these loci results in spermatogenic arrest and is associated with azoospermia, oligozoospermia and also with a varied testis histological profile ranging from Sertoli cell only (SCO) to hypospermatogenesis to maturation arrest. The average Y chromosome microdeletions for infertile males were 8.2% and majority of deletions (84.3%) were associated with azoospermia . These deletions in fertile controls have been reported to be less than 1% and no deletion has been detected in men with normal semen analysis . The genetic basis of infertility is very complex and is determined by many factors. These factors influence the development of gametes, the reproductive organs both external and internal, their physiology and the development of embryo and its further differentiation. Genetic disorders can be chromosomal, single gene mutations or can be multifactorial. Extensive research has been conducted for having a better insight into the genetic basis of infertility
5.... Genetic counseling educates the patients about the genetic make-up and any risk that may be conferred to progeny. It gives them reproductive choice also. A significant proportion of couples in reproductive age suffer from primary and secondary infertility. Although, varieties of possible causes on male infertility, as mentioned above, have been identified in majority of cases, the diagnosis of male infertility revolves around the routine semen analysis. Documented database is scary in our country that covers data on all aspects of male infertility and there is an urgent need for the same to identify the underlying causes of infertility with preventive strategies.
6.... Humans are exposed to numerous exogenous as well as environmental chemicals through various routes. During the past 50 years, the rapid expansion of chemical industries in both the developed and developing countries has resulted in release of a plethora of xenobiotics into the environment. Male reproductive system is highly sensitive to these environmental factors that lead to infertility . These alien molecules, including pesticides, herbicides, cosmetics, preservatives, cleaning materials, municipal and private wastes, pharmaceuticals and industrial by-products enter our bodies in a variety of forms. Exposure to chemical contaminants, which are estrogen mimics and endocrine disruptors, has been implicated as one of the possible factors contributing to the increasing male infertility.
7... If any working in chemical or fertilizer industry should take care of their health. I am telling about infertility may be the cause of exposing to chemicals.
8... I advise every person who supposed to expose chemicals should keep some plant in his residence to get oxygen which will nullify pesticides effect on him.
9... Drink sufficient water and eat fruits regularly
Brought to U... http://successgain.info
Brought to U....http://successgain.us and http://successgain.info
My memories
Chemical contaminants causes male infertility
Posted on 30th January 2018
The genetic basis of infertility has received increasing recognition in recent years. Several kinds of chromosomal abnormalities are associated with infertility: deletion, inversion, mutation, aneuploidy, and translocation. Of these, translocation is most common chromosomal abnormality. A study showed that the frequency of chromosomal translocations was 2.1% in infertile men. Chromosomal translocations can be of many types- Robertsonian translocation, reciprocal translocation and these account for 10% of the causes of male infertility . Robertsonian translocations are defined as translocations involving acrocentric chromosomes 13-15.21.22. Carriers of Robertsonian translocations are phenotypically normal; however, they exhibit reproductive dysfunction, such as oligospermia in males . It is now obvious that genetic etiology for infertility is an important cause of disrupted spermatogenesis. Genetic damage in sperm can occur at several levels, all of which have the potential to cause infertility in men. Sperm DNA is known to contribute one half of the genomic material to offspring. Thus, normal sperm genetic material is required for fertilization, embryo and fetal development and post-natal child well being . Various in vivo and in vitro studies have suggested that disturbances in the genomic organization in sperm nuclei are negatively correlated with the fertility potential of spermatozoa . Investigations have also shown that these disorders play an important role in failure of intracytoplasmic sperm injection (ICSI) and intrauterine insemination (IUI). In males the prevalence of genetic factors seems to be inversely related to the sperm count. Our earlier study was also documents a negative correlation between DNA damaged cells and sperm motility. There is a concern that these genetic abnormalities can be transmitted to the male progeny, who may subsequently have a more severe phenotype of infertility. The incidence of chromosome factors in infertile males ranges between 2 and 8% increased to 15% in azoospermic males in recent years . FSH is an important hormone which is required for initiation of spermatogenesis is requisite to monitor in infertile men from the point of therapeutics and clinical intervention. Normal FSH is indicative of germinal epithelial destruction, but elevated FSH is associated with both normal as well as aberrant spermatogenesis, where testicular histology could show Sertoli cell only (SCO) syndrome, Hypospermatogenesis is seen where the quantity of spermatogenesis is decreased and is known to be associated with either normal or elevated FSH. The rate of carry home alive and healthy birth is low especially when DNA damaged sperm is used in ART. Recurrent ART failure cause financial, emotional and psychological stress on the couples.
My advise
1.... Advancement in molecular biology enabled the identification and characterization of underlying genetic causes of male infertility. Genetic causes must be sought by systematic evaluation of infertile men and affected couples informed about the implications of such diagnoses for assisted reproductive technology outcome and their potential offspring. An association between human male infertility and chromosomal anomalies has been known for a long time. The incidence of karyotype abnormalities among patients with infertility has been reported to range between 2% to 21%, being low among azoospermic men
2.... .The possible association between chromosomal abnormalities and male infertility became evident following the result of the first large karyo type survey involving sub fertile males . The Y chromosome in mammals carries the gene that switches the development of the indifferent gonad from the default female pathway to the male pathway and results in the development of the testis . Long ago macroscopic deletions in the long arm of Y chromosome were suggested to be responsible for azoospermia . With the advancement in molecular biology, three non-overlapping regions, to as azoospermia factor (AZF a, b and c from proximal to distal Yq) have been defined as spermatogenesis loci
3....... The AZF microdeletions are the prevalent cause of male factor infertility. Germ cell development is under the control of a large number of genes on auto somes and on the Y chromosome. The long arm of the Y chromosome contains genes and gene families involved in spermatogenesis and are critical for germ cell development and differentiation. In 1992, Vollrath and colleagues constructed a 43 interval deletion map of a human Y chromosome that contained on ordered array of sequence tagged sites (STS) that spanned the entire length of the Y chromosome.
4..... The genes critical for spermatogenesis are located on the long arm of the Y chromosome in deletion interval 5 and 6 bend 11.23. This region is referred to as the AZF as the most severe phenotype associated with its deletion is azoospermia. The AZFa locus is located on proximal Yq11 (Yq 11.21), while AZFb and AZFc are located on distal Yq 11 (Yq 11.23). Deletion of these loci results in spermatogenic arrest and is associated with azoospermia, oligozoospermia and also with a varied testis histological profile ranging from Sertoli cell only (SCO) to hypospermatogenesis to maturation arrest. The average Y chromosome microdeletions for infertile males were 8.2% and majority of deletions (84.3%) were associated with azoospermia . These deletions in fertile controls have been reported to be less than 1% and no deletion has been detected in men with normal semen analysis . The genetic basis of infertility is very complex and is determined by many factors. These factors influence the development of gametes, the reproductive organs both external and internal, their physiology and the development of embryo and its further differentiation. Genetic disorders can be chromosomal, single gene mutations or can be multifactorial. Extensive research has been conducted for having a better insight into the genetic basis of infertility
5.... Genetic counseling educates the patients about the genetic make-up and any risk that may be conferred to progeny. It gives them reproductive choice also. A significant proportion of couples in reproductive age suffer from primary and secondary infertility. Although, varieties of possible causes on male infertility, as mentioned above, have been identified in majority of cases, the diagnosis of male infertility revolves around the routine semen analysis. Documented database is scary in our country that covers data on all aspects of male infertility and there is an urgent need for the same to identify the underlying causes of infertility with preventive strategies.
6.... Humans are exposed to numerous exogenous as well as environmental chemicals through various routes. During the past 50 years, the rapid expansion of chemical industries in both the developed and developing countries has resulted in release of a plethora of xenobiotics into the environment. Male reproductive system is highly sensitive to these environmental factors that lead to infertility . These alien molecules, including pesticides, herbicides, cosmetics, preservatives, cleaning materials, municipal and private wastes, pharmaceuticals and industrial by-products enter our bodies in a variety of forms. Exposure to chemical contaminants, which are estrogen mimics and endocrine disruptors, has been implicated as one of the possible factors contributing to the increasing male infertility.
7... If any working in chemical or fertilizer industry should take care of their health. I am telling about infertility may be the cause of exposing to chemicals.
8... I advise every person who supposed to expose chemicals should keep some plant in his residence to get oxygen which will nullify pesticides effect on him.
9... Drink sufficient water and eat fruits regularly
Brought to U... http://successgain.info
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