Sleep disturbance and Fertility in woman

Sleep disturbance and Fertility in woman








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Sleep disturbance and Fertility in woman
Posted on 2nd January 2014
The relationship between sleep and fertility is largely unknown. This paucity of research is surprising, given that sleep is such a critical component to one’s physical and emotional health and well-being. Among both women and men, it is well established that sleep disorders, particularly insomnia, contribute to, or are associated with, myriad health conditions, including cardiovascular disease, hypertension, glucose dysregulation, depression, and anxiety disorders. Specific to women, sleep disturbances coincide with premenstrual dysphoria, pregnancy, postpartum depression, and the menopausal transition . While there appears to be a relationship between sleep disturbance and reproductive health, little is known about which form of sleep disturbance is related to reproductive capacity and which specific aspects of reproductive capacity are particularly affected. With respect to sleep disturbance, the relevant domains could include sleep fragmentation, sleep continuity disturbance, short or long sleep duration, circadian dysrhythmia, and/or hypoxia. With respect to reproductive capacity, the relevant domains could include problems with fertility, conception, implantation, gestation, delivery, and/or neonatal health. Finally, it is possible that the relationship between these domains is reciprocal in nature, such that sleep disturbances and their associated sequelae may not only ensue from, but also interfere with, reproductive processes.

Sleep and sleep disturbances are increasingly recognized as determinants of women’s health and well-being, particularly in the context of the menstrual cycle, pregnancy, and menopause. At present, however, little is known about whether fertility is affected by sleep quantity and quality. That is, to what degree, and by what mechanisms, do sleep and/or its disturbances affect fertility? The purpose of this review is to synthesize what is known about sleep disturbances in relation to reproductive capacity. A model is provided, whereby stress, sleep dysregulation, and circadian misalignment are delineated for their potential relevance to infertility. Ultimately, if it is the case that sleep disturbance is associated with infertility, new avenues for clinical intervention may be possible.

My advise

1...    To date, the majority of evidence for the association between sleep disturbance and diminished reproductive capacity has been within the area of shift work

2...    In general, adverse reproductive health outcomes were observed (e.g., menstrual irregularities, dysmenorrhea, increased time to, and reduced rates for, conception, increased miscarriages, lower birth weights) and were taken to implicate the negative effects of circadian misalignment, and/or the sleep disturbance that coincides with shift work

3...    There is a more limited literature with respect to sleep disordered breathing and infertility. Polycystic Ovary Syndrome (PCOS) is known to reduce reproductive potential and is believed to be one of the most common causes of female infertility. Two key studies demonstrate the association between sleep disordered breathing and PCOS. One seminal study showed that premenopausal women with PCOS were 30 times more likely to suffer from SDB than controls 

4...    Another key study similarly showed OSA was prevalent in 44% of obese women with PCOS, compared to 6% of age- and weight-matched reproductively normal women . OSA is believed to contribute to the metabolic abnormalities (insulin resistance and decreased glucose tolerance) in women with PCOS

5..    Therefore, it is possible that OSA contributes to one form of female factor infertility. Finally, with respect to sleep continuity disturbance, only two studies have evaluated the direct association between sleep continuity disturbance and infertility. First, Pal et al. found that sleep disturbance, assessed using the single item query “do you experience disturbed sleep?”, occurred in 34% of infertile women 

6...   In addition, women with diminished ovarian reserve were found to be 30 times more likely to have disturbed sleep, while controlling for race, BMI, and vasomotor symptoms. Second, Lin and colleagues found that greater than 35% of women receiving intrauterine insemination reported disturbances in their sleep. While these studies are among the first to examine sleep disturbance in relation to successful pregnancy outcomes and in populations of infertile women, sleep disturbance was assessed globally (i.e., is phrased in such a way to be all-inclusive and non-specific with respect to individual sleep disorders).

7...    Further, the direction of the findings suggests that the observed sleep disturbance is a consequence of infertility. The purpose of the present paper is to examine the reciprocal proposition, that sleep disturbance may adversely affect fertility.

8...    Follow healthy food to have good sleep without disturbance may increase your fertility n after conceiving  your unborn child will grow peaceful, healthy and brilliant.

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C


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